Nasal polyposis is a chronic inflammatory disease of the upper airway which develops in the ethmoidal and middle turbinate area, which characterized by a number of inflammatory cells with infiltration of eosinophil, Th2 cells, mast cells, and macrophages. Nasal mucosal immune-reactivity may occur in varying degrees in polyps with allergic, local allergic, and nonallergic rhinitis. RANTES is locally produced within the nasal microenvironment of polyps and may be responsible for the eosinophil recruitment. Tumor necrosis factor (TNF) alpha with TH2 cytokines as interleukin-5 may enhance Nasal polyp fibroblast to produce inflammatory mediators. We evaluated the differences of nasal polyps from adolescents with allergic and non-allergic rhinitis for RANTES, TNF-α, and IL-5 contents. The goal of this study was to evaluate the role of allergic rhinitis in the pathogensis of nasal polyposis and the correlation between both. We recruited 29 adolescents with allergic (n=15, mean age: 17.4 yrs old), local allergic rhinitis (n=9, mean age:15.9±5.5 yrs old), and non-allergic rhinitis (n=14, mean age: 15.6 yrs old) undergoing polypectomy. Immunoassays were performed using polyp tissues homogenates to quantify the levels of RANTES, TNF-α, and IL-5 and sera to assess total IgE, eosinophil cationic protein (ECP) from them. TNF-α, IL-5, and RANTES levels in atopic polyp was higher detected compared with non-atopic polyp tissue homogenates (IL-5: allergic rhinitis: 181.5±143.6, local allergic rhinitis: 211.7±185.3, and non-allergic rhinitis: 82.7±88.3 ng/100mg, RANTES: allergic rhinitis: 174.5± 63.5 local allergic rhinitis: 198.5±102.2, and non-allergic rhinitis: 60.3±38.5 ng/100mg, TNF-α : allergic rhinitis: 180.8±121.9, local allergic rhinitis: 48.3±55.4, and non-allergic rhinitis 64.1±64.5 ng/100mg), but no significant difference in INF-γ levels was observed between them. IL-5, RANTES, and TNF-α play important role in inflammatory recruitment leading to cell activation and directional migration of Th2 specific leukocyte subsets for allergic reaction in allergic polyp. Therefore they are involved in the pathogenesis of allergic rhinitis, local allergic rhinitis with polyp.