Erythromelalgia is a rare clinical syndrome characterized by erythema, increased temperature, and severe burning pain which can be aggravated by warmth or can be relieved by cold. Erythromelalgia occurs either as a primary, idiopathic form or secondary form to a number of disease and conditions. Although fairly well studied in adults, the characteristics, pathogenesis, natural history are poorly characterized in the pediatric age group. Different therapeutic options have been tried, but no optimal treatment has been suggested for erythromelalgia.We report a rare case of erythromelalgia in a 12-year old girl involving the central body with vasculitis feature. It seems to be a secondary due to vasculitis, but it is uncertained. The erythema was visible as red lines that seemed to follow her vessels and the pain was progressive which was sensitive to heat. Her left upper arm was first, then the pain appeared to cross her torso and afflict her right arm as well, finally resulting in her complaining of bilateral numbness in her hands and feet. We started with a regimen of dexamethasone for 3 days, followed by prednisone, aspirin and propranolol. However, the pain had crossed her torso and afflicted both her legs and then she complained heat sensation whenever she urinated, accompanied by vasculitis-like burning sense that affected her torso and it also seems to be invaded both of ears. Her clinical progress showed wax and wane with aspirin and propranolol.Especially in pediatric cases such as ours, psychological support is of utmost importance. Because the occurrence of the disease is quite rare, research on the pathophysiology and treatment of erythromelalgia should be performed collaborately.