BACKGROUND: Atherosclerosis and obesity-induced metabolic dysfunction are lipid/glucose-driven inflammatory pathologies responsible for cardiovascular complications. This study investigated the relationship between clinical/laboratory parameters and atherosclerosis, measured as common carotid artery intima-media thickness (CIMT), in children with obesity. METHODS: This study included 25 children with obesity (body mass index [BMI]  95 percentile). We evaluated children (mean age, 11.17 ± 3.09 years) who participated in the general health examination program between March 2014 and December 2014. We performed anthropometric measurements and laboratory tests, including an oral glucose tolerance test (OGTT). Both the left and right CIMTs were measured in all of the patients by one researcher. RESULTS: Of the children evaluated, 25 who had obesity (n = 17 boys and n = 8 girls; aged 10–14 years) volunteered to participate in the study. Mean CIMT of both sides, age, BMI, blood pressure, lipid profile, OGTT results, and HbA1c level did not significantly differ between the children. Right CIMT was correlated only with left CIMT. Age, BMI, lipid profile, serum c-peptide level, serum insulin level, and homeostasis model assessment of insulin resistance were not related to right or left CIMT. Simple correlation analyses showed that fasting plasma glucose ( PG; γ = 0.430, p = 0.032), PG60min (γ = 0.424, p = 0.035), PG90min (γ = 0.485, p = 0.014), PG120min (γ = 0.456, p = 0.022), HbA1c level (γ = 0.509, p = 0.009), amount of PG increase at 90 min ( PG△90; γ = 0.493, p = 0.012), and PG△120 (γ = 0.459, p = 0.021) were significantly correlated with left CIMT. Multiple regression analysis using left CIMT as a dependent variable and age, BMI, and OGTT results as independent variables showed that HbA1c level was only significantly and positively correlated with left CIMT (β = 0.080, p = 0.009). CONCLUSION: These findings show that left CIMT changes earlier than right CIMT in children with obesity and is related to glucose intolerance state. Thus, early lifestyle modification to attain a reasonable glucose metabolism will lower cardiovascular risk.