Background Chest pain is common chief complaint of many children visiting hospital. Cardiac diseases are rare in these patients, but evaluation should be done to rule out underlying disease. In this paper, we investigated cardiac function with echocardiographic measurements between patients with chest pain and healthy children Methods and results: Chest pain group enrolled 29 children with chest pain (Mean age 10.2 years, BSA 1.22m2) and healthy control group includes 70 (Mean age 11.9 years, BSA 1.36m2), who visited the pediatric cardiology outpatient department during January 2014 till August 2014. All these children underwent echocardiography. The parameters of conventional echocardiography and tissue Doppler imaging (TDI) were aquired and standardized by body surface area (BSA) and body weight (BW). At the systolic phase, interventricular septum (IVS S), left ventricular end systolic and diastolic diameters (LVESD and LVEDD), left ventricular posterior wall thickness (LVPW) standardized by BSA were significantly increased in chest pain group (IVS S/BSA 7.93±2.04 versus 7.28±1.38, p value = 0.04 ; LVEDD /BSA 34.72±7.90 versus 32.91±5.99, p value = 0.02 ; LVESD /BSA 22.33±5.63 versus 21.55±4.05, p value = 0.007 ; LVPW S/BSA 7.92±2.15 versus 7.44±1.46, p value = 0.008). In TDI parameters, E’, A’, S’ standardized by BW, BSA was increased in patients with chest pain (TDI E’ /BW 0.043±0.019 versus 0.034±0.013, p value = 0.03 ; TDI A’/BW 0.016±0.009 versus 0.013±0.005, p value = 0.004 ; TDI S’/BW 0.022±0.009 versus 0.018±0.007, p value = 0.03 ; TDI E’/BSA 1.232±0.388 versus 1.037±0.257, p value = 0.03 ; TDI A’/BSA 0.472±0.201 versus 0.397±0.112, p value = 0.008 ; TDI S’/BSA 0.633±0.182 versus 0.549±0.132, p value = 0.02). Conclusion LV dimension, wall thickness in systolic phase, and myocardial velocities were significantly different in chest pain group. Even though the general cardiac function is reasonable in chest pain group, it would be better in close observation for predicting future myocardial function.