30-33주 미숙아에서의 미숙아 망막증 발생 관련 인자
ROP screening in 'sick' moderately preterm infants
Abstract
Objective: Retinopathy of prematurity (ROP) screening guidelines vary around the world. While developed countries seek to lower the gestational age and birthweight parameters, relatively older, larger infants still suffer from ROP in other parts of the world. Our aim was to define ‘sickness criteria’ for screening ROP in moderately preterm infants to complement current guidelines. Methods: A retrospective medical record review was performed in 147 inborn infants admitted to the neonatal intensive care unit (NICU) during the study period. Univariate and logistic regression analysis was executed to find out potential risk factors of ROP. Result: Forty-two infants developed ROP. Gestational age (31.4 ± 1.1 vs. 32.4 ± 1.0 weeks, p = 0.000) and birthweight (1607.7 ± 339.4 vs. 1846.4 ± 317.2 g, p = 0.000) tended to be lower in those who developed ROP. Respiratory distress syndrome (RDS) (p = 0.026), and documented sepsis (p = 0.003) were significant comorbidities in univariate analysis. While birthweight did not hold statistical significance in the logistic regression model, inotrope(s) need for longer than 72 h started in the 1st week of life (p = 0.004, odds ratio 5.181) and more than three administrations of pack red blood cell ( PRC) transfusion (p = 0.028, odds ratio = 3.891) were also significant, both in univariate and multivariate analyses. Conclusion: In moderately preterm infants, variable ‘sickness’ statuses should be evaluated in order to effectively select candidates for ROP screening without missing potential victims of ROP.